Why the study?
Only a few large-scale studies have evaluated the clinical utility of red cell distribution width (RDW) in heart failure after adjusting for covariates affecting RDW.
Does elevated RDW predict all-cause mortality in patients with heart failure?
Population
6599 patients diagnosed with HF from three referral hospitals
Comparison
Elevated RDW vs lower RDW
Design
Retrospective multicenter cohort study
Follow-up
Median 887 days
Key result
Elevated red cell distribution width at initial heart failure diagnosis was independently associated with increased all-cause mortality (30.2% vs 11.2%; HR 1.11; 95% CI 1.06-1.16; P<0.001).
Authors
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May aid early HF risk stratification; leaves open incremental value beyond NT-proBNP in prospective studies.
Cohort (n=6,599)
Yes
Does elevated RDW predict all-cause mortality in patients with heart failure?
Effect estimate: HR 1.11 (95% CI 1.06-1.16)
Absolute Event Rate: 30.2% vs 11.2%
p-value: p=<0.001
Elevated RDW at the time of heart failure diagnosis is an independent predictor of all-cause mortality, providing incremental prognostic value beyond traditional risk factors and NT-proBNP.
Kim et al. (2022) conducted a cohort in Heart failure (n=6,599). Elevated Red Cell Distribution Width (RDW) vs. Non-elevated RDW was evaluated on All-cause mortality (HR 1.11, 95% CI 1.06-1.16, p=<0.001). Elevated red cell distribution width at initial heart failure diagnosis was independently associated with increased all-cause mortality (30.2% vs 11.2%; HR 1.11; 95% CI 1.06-1.16; P<0.001).