Comparative Indium-111 antimyosin and thallium-201 SPECT imaging classified patients into 5 scintigraphic patterns useful for evaluating myocarditis activity and ongoing myocardial damage.
Observational
Does comparative Indium-111 antimyosin and thallium-201 SPECT imaging correlate with histologic findings for evaluating myocarditis and dilated cardiomyopathy?
Comparative Indium-111 antimyosin and thallium-201 SPECT imaging is useful for evaluating myocarditis activity and ongoing myocardial damage in patients with dilated cardiomyopathy.
Indium-111 antimyosin antibody imaging (a tracer of myocardial necrosis) and thallium-201 imaging (a tracer of myocardial perfusion) were compared in patients with myocarditis and dilated cardiomyopathy. The distribution of each tracer and antimyosin/thallium-201 overlapping were evaluated with single-photon emission computed tomography (SPECT). Scintigraphic data were classified into 5 patterns according to the distribution of both images and were compared with histologic findings of endomyocardial biopsy: AM-D, intense and diffuse antimyosin uptake and no perfusion abnormality (active myocarditis); AM-L, localized antimyosin up-take and no perfusion abnormality (active myocarditis); HM, no antimyosin uptake with or without perfusion abnormality (healed myocarditis); DCM-NH, diffuse antimyosin uptake and inhomogeneous thallium-201 uptake (dilated cardiomyopathy); DCM-PD, diffuse or localized antimyosin uptake and myocardial perfusion defect(s) (dilated cardiomyopathy). Patients with dilated-phase hypertrophic cardiomyopathy were frequently found in the DCM-PD group. Taken together, comparative antimyosin/thallium-201 SPECT images are useful for evaluating the activity of myocarditis and ongoing myocardial damage even in areas with no perfusion in patients with dilated cardiomyopathy. (Jpn Circ J 1997; 61: 827 - 835)
Yamada et al. (1997) conducted an observational in Myocarditis and dilated cardiomyopathy. Indium-111 antimyosin antibody and thallium-201 SPECT imaging vs. Endomyocardial biopsy was evaluated on Scintigraphic patterns compared with histologic findings of endomyocardial biopsy. Comparative Indium-111 antimyosin and thallium-201 SPECT imaging classified patients into 5 scintigraphic patterns useful for evaluating myocarditis activity and ongoing myocardial damage.