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May 29, 2026ACS Applied Materials & Interfaces0 citations

Functional Performance of Silk Nanoparticles for Oral Drug Delivery

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CJCharlotte JacobusSSSawnaz ShaidaniETEmma Tonies

Key Points

  • This study aims to evaluate the efficacy of silk nanoparticles (SNPs) in enhancing the oral bioavailability of peptide-based drugs.
  • Developed an intestinal tissue model to test SNPs and their interactions with intestinal epithelial tight junctions.
  • Assessed the loading efficiency, sustained release, and bioactivity of the peptide semaglutide after SNP loading under simulated intestinal conditions.
  • SNPs exhibited a high loading efficiency of over 80% for semaglutide.
  • Peptide drugs showed improved permeation and bioavailability with the transient opening of tight junctions after SNP exposure.
  • SNPs maintained drug bioactivity and exhibited a slow degradation profile, preserving drug integrity during intestinal transit.

Abstract

intestinal tissue model. Intestine epithelial tight junctions transiently opened after exposure to all particle types and then recovered, suggesting improved permeation of peptide drugs and thus higher bioavailability. SNPs provided high loading efficiency (>80%), sustained release of loaded semaglutide with bioactivity maintained after loading, and exhibited slow degradation under simulated intestinal enzymatic conditions, preserving drug integrity during transit to support oral delivery goals. These findings highlight the potential of SNPs to overcome key GI tract barriers and significantly improve the oral bioavailability of sensitive peptide-based therapeutics.

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Cite This Study

Jacobus et al. (2026) studied this question.

synapsesocial.com/papers/6a192d4afab5b468c44161c4https://doi.org/10.1021/acsami.6c06529
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