A novel bio-capable method has been implemented for the synthesis of newly substituted derivatives of perimidine using Fe3O4@nano-cellulose/Ti(IV) as a magnetic, sustainable, and eco-friendly Lewis acid nanocatalyst. The catalyst was thoroughly characterized by XRD, FESEM, and TGA analyses, confirming its crystalline structure, uniform nanoscale morphology, and high thermal stability. The reaction proceeded smoothly in eco-friendly solvents, providing outstanding yields under mild and rapid conditions, especially with ultrasonics. The catalyst, derived from renewable materials, exhibited remarkable activity, easy magnetic recovery, and excellent reusability over several cycles without significant loss of efficiency. Spectral characterization, IR, 1H NMR, 13C NMR, 19F NMR, and HRMS analyses verified that perimidine derivatives were synthesized properly. This sustainable and efficient approach demonstrates the prospect of green Lewis acid nanocatalysts for the sustainable synthesis of valuable heterocyclic compounds.
Pasdar et al. (2026) studied this question.