Irritation fibroma is a common benign reactive lesion of the oral mucosa, typically resulting from chronic mechanical irritation. While generally small and asymptomatic, rare cases may exhibit atypical growth. This report presents a 37-year-old male patient with a 2.7 cm fibroma located on the hard palate. Complete surgical excision was performed, and histopathological examination confirmed the diagnosis of irritation fibroma with no evidence of dysplasia or malignancy. Postoperative management included the use of a chairside-fabricated zinc-infused palatal stent, combined with topical oxygen- and lactoferrin-containing oral gel, to support wound protection during secondary healing. The postoperative course was uneventful, with satisfactory mucosal healing and no recurrence observed at one-year follow-up. This case presents the clinical presentation and management of an unusually large palatal irritation fibroma and highlights a supportive postoperative protocol that may constitute a useful adjunct in oral wound healing.
Leventis et al. (2026) studied this question.