Brain metastases are rare, yet severe manifestations of prostate cancer that present with symptoms such as severe headaches, seizures, confusion, and memory deficits. Here we describe a unique case of a 77-year-old patient with a history of Gleason 3+4 prostate cancer nearly a decade prior that was determined to have brain metastasis due to similar symptoms. Utilization of imaging tools, including non-contrast CT scans, susceptibility-weighted imaging, and MRIs, helped with assessment of the lesion, and histopathological analysis guided treatment. This case highlights the importance of considering delayed brain metastasis in patients with prior prostate cancer and new neurological deficits. Prompt radiological evaluation and pathologic confirmation are essential for accurate diagnosis and management.
Arumugam et al. (2026) studied this question.