Continuous activity monitoring with an AI-driven chatbot significantly reduced hospitalizations compared to nursing triage (11% vs 39%, p=0.01) but resulted in inferior global quality of life.
RCT (n=77)
No
Does continuous activity monitoring with an AI-driven chatbot reduce hospitalizations and improve quality of life in patients receiving concurrent chemoradiotherapy compared to nursing triage?
While an AI-driven chatbot combined with continuous activity monitoring reduced hospitalizations in patients undergoing chemoradiotherapy, it resulted in inferior quality of life compared to human nursing triage.
Absolute Event Rate: 11% vs 39%
p-value: p=0.01
12132 Background: Toxicities associated with concurrent chemoradiotherapy (CRT) can lead to hospitalizations and impaired quality of life (QoL). This study reports on secondary endpoints investigating whether combining continuous activity monitoring (CAM) with an AI-driven chatbot can support symptom identification, triage, reduce hospitalizations, and improve QoL. Methods: Patients receiving CRT for head and neck (H 39%, n=14 nursing triage, p=0.01). On logistic regression, subjects on the chatbot arm (p=0.0125) and those who had ECOG 0 (p=0.0131) were less likely to be hospitalized. In both arms, global QoL/health, fatigue, and physical, social, cognitive, and emotional functioning declined during CRT. Chatbot subjects had significantly inferior global QoL/Health status (p=0.049), cognitive functioning (p=0.005), and physical functioning (p=0.02) vs nursing triage. Conclusions: Patients undergoing CRT experience functional decline. While AI-driven chatbots may reduce hospitalizations, they are not a perfect substitute for a compassionate healthcare team. An analysis of alerts and triage visits will be reported with our primary endpoint.
Hollawell et al. (2026) conducted an RCT in Head and neck, gastrointestinal, or thoracic cancers undergoing concurrent chemoradiotherapy (n=77). Continuous activity monitoring with AI-driven chatbot triage vs. Continuous activity monitoring with nursing triage was evaluated on Hospitalizations during CRT and one month post treatment (p=0.01). Continuous activity monitoring with an AI-driven chatbot significantly reduced hospitalizations compared to nursing triage (11% vs 39%, p=0.01) but resulted in inferior global quality of life.