Why the study?
Evidence regarding aspirin in sepsis patients with AF remains limited, and exposure timing complicates interpretation.
Does early aspirin exposure reduce mortality in sepsis patients with atrial fibrillation?
Population
8,827 sepsis patients with AF in MIMIC-IV with external validation in eICU-CRD
Comparison
Aspirin exposure before or within 48 h of ICU admission vs no aspirin within 48 h
Design
Retrospective cohort study with external validation
Follow-up
30 days
Key result
Early aspirin exposure within 48 hours of ICU admission was associated with a significantly lower 30-day all-cause mortality (HR 0.624) in sepsis patients with atrial fibrillation.
Authors
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Should not yet change practice in sepsis with AF; hypothesis-generating and supports RCTs to confirm mortality benefit.
Cohort (n=8,827)
Yes
Does early aspirin exposure reduce mortality in sepsis patients with atrial fibrillation?
Effect estimate: HR 0.624 (95% CI 0.547-0.712)
p-value: p=<0.001
Early aspirin exposure is associated with lower 30-day mortality in sepsis patients with atrial fibrillation, particularly when newly initiated during early ICU care.
Chen et al. (2026) conducted a cohort in Sepsis with atrial fibrillation (n=8,827). Early aspirin exposure vs. No aspirin exposure within 48 hours after ICU admission was evaluated on 30-day all-cause mortality (HR 0.624, 95% CI 0.547-0.712, p=<0.001). Early aspirin exposure within 48 hours of ICU admission was associated with a significantly lower 30-day all-cause mortality (HR 0.624) in sepsis patients with atrial fibrillation.