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July 21, 2006Angewandte Chemie International Edition79 citations

MicroRNAs—Future Drug Targets?

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CAChristoph Arenz

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Abstract

Big things come in small packages: MicroRNAs (miRNAs) are small regulatory RNA molecules in eukaryotes. Altered miRNA expression patterns can be used as a diagnostic tool, for example, in patients with chronic lymphatic leukemia. Also, the inhibition of miRNA function in vivo has been recently achieved by using “antagomirs”—antisense cholesterol conjugates (see scheme; miRNP=miRNA–protein complex, RISC=RNA-induced silencing complex).

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Cite This Study

Christoph Arenz (2006) studied this question.

synapsesocial.com/papers/6a19c4b760e90a7f5feaa583https://doi.org/10.1002/anie.200601537
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