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January 28, 2007American Journal of Hypertension

Impact of Blood Pressure Variability on Cardiac and Cerebrovascular Complications in Hypertension

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Why the study?

Does high blood pressure variability predict cardiac and cerebrovascular events in initially untreated hypertensive subjects?

Population

2649 initially untreated subjects with essential hypertension

Comparison

High blood pressure variability vs Low blood pressure variability (≤ group median)

Design

Cohort

Follow-up

up to 16 years (mean, 6)

Authors

PVP. VerdecchiaFAFabio AngeliRGRoberto Gattobigio

Discussion

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Overview

May support risk stratification in untreated hypertension; leaves open whether targeting variability improves outcomes.

Key Points

  • This research aims to explore how variability in blood pressure affects the risk of cardiac and cerebrovascular complications in people with hypertension.
  • Followed 2649 subjects with essential hypertension for up to 16 years (mean 6 years).
  • Calculated variability of blood pressure using standard deviation of daytime and night-time systolic and diastolic BP.
  • Identified subjects as low or high variability based on group median values of daytime and night-time BP.
  • Higher rates of cardiac events observed in high BP variability group: daytime SBP 1.45 vs. 0.72, night-time SBP 1.58 vs. 0.62, all P < .05.
  • Increased cerebrovascular events were also associated with high BP variability, all P < .05.
  • High night-time SBP variability correlates with a 51% increased risk of cardiac events (P = .024) after adjusting for confounders.

Structured PICO

Does high blood pressure variability predict cardiac and cerebrovascular events in initially untreated hypertensive subjects?

P
Population
2649 initially untreated subjects with essential hypertension
I
Intervention
High blood pressure variability (> group median: 12.7/10.4 mm Hg for daytime SBP/DBP and 10.8/8.9 mm Hg for night-time SBP/DBP)
C
Comparator
Low blood pressure variability (≤ group median)
O
Outcome
Cardiac and cerebrovascular eventshard clinical

Enhanced night-time systolic blood pressure variability is an independent predictor of cardiac events in untreated hypertensive patients.

Cite This Study

Verdecchia et al. (2007) studied this question.

synapsesocial.com/papers/6a19e39e05af093a17f6b4dehttps://doi.org/10.1016/j.amjhyper.2006.07.017
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