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December 9, 2021Frontiers in PhysiologyOpen Access

A closed-loop multiscale computational model of human blood circulation successfully simulated multidimensional ballistocardiography signals, revealing non-negligible contributions from cardiac chambers and pulmonary circulation.

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Why the study?

Many ballistocardiography findings are based on parameters whose physiological origins are poorly understood.

Population

Anatomical data from whole-body magnetic resonance angiography of 1 healthy young subject

Design

Computational modeling study

Key result

A closed-loop multiscale computational model of human blood circulation successfully simulated multidimensional ballistocardiography signals, revealing non-negligible contributions from cardiac chambers and pulmonary circulation.

Authors

JRJérémy RabineauANAntoine NonclercqTLTim Leiner

Discussion

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Overview

Hypothesis-generating for BCG interpretation; leaves open prospective clinical validation before diagnostic use.

Structured PICO

P
Population
Computational model based on whole-body magnetic resonance angiography of a single healthy young subject
I
Intervention
Closed-loop 0D-1D multiscale computational model of human blood circulation (including 55 systemic and 57 pulmonary arteries, cardiac chambers, valves, and microcirculation)
O
Outcome
Simulated multidimensional ballistocardiography (BCG) signalsurrogate

A novel closed-loop multiscale computational model of blood circulation accurately simulates multidimensional BCG signals, highlighting the significant contribution of cardiac chambers and pulmonary circulation.

Limitations

  • Regulatory mechanisms such as the baroreflex are not included in the model
  • Respiratory movements and displacement of the heart and vessels are neglected
  • Blood is assumed to be a Newtonian fluid, limiting the 1D model to larger arteries
  • The 1D model is limited to 55 systemic and 57 pulmonary arteries
  • Neglects respiratory movements and displacement of heart/vessels
  • Regulatory mechanisms like baroreflex are not included
  • Only periodic solutions are considered

Cite This Study

Rabineau et al. (2021) studied Healthy (n=1). Closed-loop 0D-1D multiscale computational model was evaluated on Simulated multidimensional ballistocardiography (BCG) signals. A closed-loop multiscale computational model of human blood circulation successfully simulated multidimensional ballistocardiography signals, revealing non-negligible contributions from cardiac chambers and pulmonary circulation.

synapsesocial.com/papers/6a1a2aaf9dd58c84b95b5ea6https://doi.org/10.3389/fphys.2021.734311
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