Children with celiac disease had significantly lower left ventricular longitudinal and radial strains compared to healthy controls, suggesting 2DSTE can detect subclinical carditis.
Observational (n=132)
Does celiac disease affect left ventricular mechanics in children as measured by two-dimensional speckle tracking echocardiography?
Two-dimensional speckle tracking echocardiography can detect subclinical left ventricular mechanical dysfunction in children with celiac disease, particularly those with active autoantibodies.
BACKGROUND: An association between cardiomyopathy and celiac disease has been reported, but not frequently. We examined the effects on cardiac mechanics in children with celiac disease (CD) by two-dimensional speckle tracking echocardiography (2DSTE). METHODS: Eighty-one children with CD were compared with a control group comprising 51 healthy children by echocardiographic examination. Children with CD who had been on gluten-free diet for more than 6 months were divided into two different groups: group 1 was positive for serum antitissue transglutaminase antibody (n=48), and group 2 was negative for serum antitissue transglutaminase antibody (n=33). Cardiac functions were evaluated in all children using conventional echocardiography, tissue Doppler imaging (TDI), and 2DSTE methods. RESULTS: For children with CD, the mean age and male:female ratio were 10.1±4.0 years and 26/55 (67% female), respectively, which did not differ from the controls. Patients were diagnosed at a mean age of 7.9±4.1 years, and the mean follow-up time was 2.37±2.98 years. Conventional echocardiography and TDI measurements did not differ between groups. The left ventricular longitudinal and radial strains, and strain rate values were significantly lower in patients with CD, particularly in those with positive antitissue transglutaminase antibody compared with the control group. CONCLUSIONS: Our results suggest that 2DSTE is superior to conventional and TDI echocardiography for evaluating subclinical carditis in children with CD.
Devecí et al. (2017) conducted an observational in Celiac disease (n=132). Celiac disease (exposure) vs. Healthy children was evaluated on Left ventricular longitudinal and radial strains, and strain rate values. Children with celiac disease had significantly lower left ventricular longitudinal and radial strains compared to healthy controls, suggesting 2DSTE can detect subclinical carditis.