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May 31, 2026Letters in Drug Design & Discovery0 citationsOpen Access

USP13 stabilizes EPHA2 to promote M2 macrophage polarization and cervical cancer progression

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TQTingting QiFZFanye ZengTXTingchuan Xiong

Key Points

  • This research explores how USP13 contributes to the stabilization of EPHA2 and its role in M2 macrophage polarization in cervical cancer progression.
  • Analyzed the interaction between USP13 and EPHA2, focusing on the deubiquitination process.
  • Examined the effects of USP13 on M2 macrophage polarization and cervical cancer cell behavior in vivo.
  • USP13 significantly stabilizes EPHA2, enhancing M2 macrophage polarization.
  • In vivo studies show increased tumor growth linked to the USP13/EPHA2 axis.

Abstract

• EPHA2 drives cervical cancer progression by inducing M2 macrophage polarization. • USP13 stabilizes EPHA2 protein by mediating the deubiquitination. • USP13 targets EPHA2 to affect M2 macrophage polarization and cervical cancer cell progression. • USP13/EPHA2 promotes tumor growth and M2 macrophage polarization in vivo .

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Cite This Study

Qi et al. (2026) studied this question.

synapsesocial.com/papers/6a1bcfb05783ba022b6fbaa7https://doi.org/10.1016/j.lddd.2026.100423
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