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May 31, 2026DNA repair0 citationsOpen Access

XPC and global genome nucleotide excision repair are essential for telomere stability after UVC-induced DNA damage in human cells

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ADAriana DetwilerABAdam BarsoukMRMariarosaria De Rosa

Key Points

  • This research aims to investigate the role of XPC and global genome nucleotide excision repair in maintaining telomere stability after UVC-induced DNA damage.
  • Examined repair efficiency of UV photoproducts in XPC and XPA deficient human cells.
  • Assessed transcription coupled NER and its inability to compensate for global genome NER at telomeres.
  • Analyzed telomere transcript levels following UVC irradiation in NER deficient cells.
  • XPC and XPA deficient cells show significantly reduced repair of UV photoproducts at telomeres.
  • Transcription coupled NER does not effectively repair telomeres in global genome NER deficient contexts.
  • Following UVC irradiation, specific telomere transcripts are upregulated in NER deficient cells.

Abstract

• XPC and XPA deficient human cells lack significant repair of UV photoproducts at telomeres. • Transcription coupled NER cannot compensate for global genome NER at telomeres. • UVC irradiation causes upregulation of some telomere transcripts in NER deficient cells. • Global NER and XPC are required for telomere stability following UVC irradiation.

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Cite This Study

Detwiler et al. (2026) studied this question.

synapsesocial.com/papers/6a1bcfb05783ba022b6fbad4https://doi.org/10.1016/j.dnarep.2026.103942
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