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May 31, 2026Cancers0 citationsOpen Access

Reply to Borewad et al. Comment on “Rao et al. The Oncological Outcome of Postoperative Radiotherapy in Patients with Node-Negative Early-Stage (T1/T2/N0) Oral Squamous Cell Carcinoma and Perineural Invasion: A Meta-Analysis. Cancers 2025, 17, 862”

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KRKarthik N. RaoSMSreeram MPRBRemco de Bree

Key Points

  • To address comments made by Borewad et al. on the meta-analysis regarding oncological outcomes in patients with specific early-stage oral cancer.
  • Engaged in a structured correspondence regarding the critiques of the original meta-analysis.
  • Evaluated the assumptions and methodologies discussed by Borewad et al.
  • Clarified the implications of postoperative radiotherapy on oncological outcomes for node-negative oral squamous cell carcinoma with perineural invasion.

Abstract

We sincerely thank Borewad et al ...

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Cite This Study

Rao et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd2845783ba022b6fdf3bhttps://doi.org/10.3390/cancers18111778
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comment on Rao et al. The Oncological Outcome of Postoperative Radiotherapy in Patients with Node-Negative Early-Stage (T1/T2/N0) Oral Squamous Cell Carcinoma and Perineural Invasion: A Meta-Analysis. Cancers 2025, 17, 8622026 · 1 citations
  2. 2Perineural invasion: Independent prognostic factor in oral cancer that warrants adjuvant treatment2018 · 114 citations
  3. 3The Impact of Perineural Invasion and/or Lymphovascular Invasion on the Survival of Early-Stage Oral Squamous Cell Carcinoma Patients2013 · 95 citations
  4. 4The Oncological Outcome of Postoperative Radiotherapy in Patients with Node-Negative Early-Stage (T1/T2/N0) Oral Squamous Cell Carcinoma and Perineural Invasion: A Meta-Analysis2025 · 13 citations
  5. 5Adjuvant radiotherapy mitigates impact of perineural invasion on oncologic outcomes in early-stage oral cavity squamous cell carcinoma. A multi-institutional analysis of 557 patients2023 · 22 citations