What does this research mean for the field?

Physiological and pathological cardiac hypertrophy are regulated by distinct protein kinase cascades, with normal growth driven by the PI3K/Akt pathway and pathological growth driven by the Gq/phospholipase C and PKC pathways. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 2005Journal of Clinical Investigation615 citationsOpen Access

Protein kinase cascades in the regulation of cardiac hypertrophy

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Population

Animal models and human condition of cardiac hypertrophy

Design

Review

Authors

GDGerald W. Dorn TFThomas Force

Discussion

Member takes

Overview

Distinguishes physiologic from pathologic hypertrophy signaling; leaves open targeted interventions for each pathway.

Structured PICO

Population

Animal models and human condition of cardiac hypertrophy

This review highlights the distinct protein kinase signaling pathways—PI3K/Akt for physiologic growth and Gq/PLC/PKC for pathologic growth—that regulate different forms of cardiac hypertrophy.

Cite This Study

Dorn et al. (2005) studied this question.

synapsesocial.com/papers/6a1bee67ea84844e355f2fee https://doi.org/10.1172/jci24178

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March 1, 2005Journal of Clinical Investigation615 citationsOpen Access

Protein kinase cascades in the regulation of cardiac hypertrophy

View Full Paper

Ask AI

Bookmark

Population

Animal models and human condition of cardiac hypertrophy

Design

Review

Authors

GDGerald W. Dorn TFThomas Force

Discussion

Member takes

Overview

Distinguishes physiologic from pathologic hypertrophy signaling; leaves open targeted interventions for each pathway.

Structured PICO

Population

Animal models and human condition of cardiac hypertrophy

This review highlights the distinct protein kinase signaling pathways—PI3K/Akt for physiologic growth and Gq/PLC/PKC for pathologic growth—that regulate different forms of cardiac hypertrophy.

Cite This Study

Dorn et al. (2005) studied this question.

synapsesocial.com/papers/6a1bee67ea84844e355f2fee https://doi.org/10.1172/jci24178

View Full Paper

Ask AI

Bookmark