Postoperative atrial fibrillation after valvular surgery was associated with lower 12-year survival compared to no POAF (45.7% vs 61.4%; HR 1.17, 95% CI 1.00-1.38, p=0.051).
Cohort (n=2,986)
No
Does postoperative atrial fibrillation reduce long-term survival in patients undergoing first valvular surgery?
Postoperative atrial fibrillation is associated with reduced long-term survival following aortic valve replacement, but not mitral valve surgery.
Effect estimate: HR 1.17 (95% CI 1.00 to 1.38)
Absolute Event Rate: 45.7% vs 61.4%
p-value: p=0.051
Background Postoperative atrial fibrillation (POAF) has been reported to be associated with reduced long-term survival after isolated coronary artery bypass grafting surgery. The objective of this study was to determine the impact of POAF on long-term survival after valvular surgery. Methods The authors retrospectively analysed the preoperative and operative data of 2986 consecutive patients with no preoperative history of atrial fibrillation undergoing first valvular surgery (aortic-valve replacement (AVR), mitral valve replacement or mitral valve repair (MVR/MVRp) with or without coronary artery bypass grafting surgery) in their institution between 1995 and 2008 (median follow-up 5.31 years, range 0.1–15.0). The authors investigated the impact of POAF on survival using multivariable Cox regression. Results Patients with POAF were older, and were more likely to have hypertension or renal failure when compared with patients without POAF. The 12-year survival in patients with POAF was 45.7±2.8% versus 61.4±2.1% in patients without POAF (pConclusions POAF is significantly associated with long-term mortality following AVR but not after MVR/MVRp. The underlying factors involved in the pathogenesis of POAF after MVR/MVRp may partially account for the lack of association between POAF and survival in these patients.
Christopher Butler (2005) conducted a cohort in First valvular surgery (n=2,986). Postoperative atrial fibrillation vs. No postoperative atrial fibrillation was evaluated on Long-term survival (all-cause death) (HR 1.17, 95% CI 1.00 to 1.38, p=0.051). Postoperative atrial fibrillation after valvular surgery was associated with lower 12-year survival compared to no POAF (45.7% vs 61.4%; HR 1.17, 95% CI 1.00-1.38, p=0.051).