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May 1, 1970Proceedings of the National Academy of Sciences481 citationsOpen Access

Regulation of Axon Formation by Clonal Lines of a Neural Tumor

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NSNicholas W. SeedsUniversity of New MexicoAGAlfred G. GilmanCancer Prevention and Research Institute of TexasTATakehiko AmanoNational Institutes of Health

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Abstract

Clonal lines of neuroblastoma cells were found to extend or retract axons depending upon the concentration of serum. Neurite extension was not inhibited by cycloheximide but was sensitive to colchicine or vinblastine, suggesting that neurite formation is dependent upon the assembly of microtubules or neurofilaments from preformed protein subunits.

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Cite This Study

Seeds et al. (1970) studied this question.

synapsesocial.com/papers/6a1c25fed54006be995fa0d4https://doi.org/10.1073/pnas.66.1.160
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