Why the study?
Cardiovascular diseases remain a major global cause of mortality driven partly by oxidative stress and inflammation, prompting evaluation of the cardioprotective potential of polyphenol-rich Citrullus lanatus rind extract against doxorubicin-induced cardiotoxicity.
Does polyphenol-rich Citrullus lanatus rind extract mitigate doxorubicin-induced cardiotoxicity in rats?
Population
30 healthy male Wistar Kyoto rats
Comparison
PRCL extract at 250 or 500 mg/kg/day vs quercetin vs control in doxorubicin-treated rats
Design
In vivo randomized animal study with in vitro assay
Follow-up
21 days
Key result
Polyphenol-rich Citrullus lanatus rind extract (500 mg/kg/day) mitigated doxorubicin-induced cardiotoxicity in rats, restoring antioxidant biomarkers and reducing inflammatory cytokines.
Authors
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Should not yet change doxorubicin cardiotoxicity management; leaves open translation of rat findings to human trials.
Does polyphenol-rich Citrullus lanatus rind extract mitigate doxorubicin-induced cardiotoxicity in rats?
Polyphenol-rich Citrullus lanatus rind extract demonstrates antioxidant and cardioprotective properties against doxorubicin-induced cardiotoxicity in a rat model.
Bader Alsuwayt (2025) studied Doxorubicin-induced cardiotoxicity (n=30). Polyphenol-rich Citrullus lanatus (PRCL) rind extract vs. Doxorubicin alone and standard quercetin was evaluated on Cardiovascular markers, antioxidant biomarkers, lipid peroxidation, and inflammatory cytokines. Polyphenol-rich Citrullus lanatus rind extract (500 mg/kg/day) mitigated doxorubicin-induced cardiotoxicity in rats, restoring antioxidant biomarkers and reducing inflammatory cytokines.