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June 1, 2026Organic Letters0 citations

C( sp 3 )–H Activation/Cleavage of Alcohols and C–C Coupling with Nonactivated Alkenes through Rhodium Catalysis Triggered by O 2

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XWXie Wen-pingZCZhi‐Min ChenKLKa Lu

Key Points

  • The central aim is to explore C–H activation of alcohols for C–C coupling with unactivated alkenes.
  • Utilized rhodium catalysis triggered by O2 for the transformation.
  • Examined a variety of secondary alcohols under mild conditions.
  • Focused on chemo- and regioselectivity and measured atom economy.
  • Achieved yields of secondary alcohols ranging from 11% to 92%.
  • Process demonstrated 100% atom economy.
  • Mechanistic studies confirmed a pathway involving C-H activation and radical addition.

Abstract

)-H activation of alcohols, enabling C-C coupling with nonactivated alkyl-substituted alkenes. The transformation proceeds with high chemo- and regioselectivity and achieves 100% atom economy. A variety of secondary alcohols are synthesized in yields of 11% to 92% under simple and mild conditions. Mechanistic studies indicate that the reaction proceeds via a C-H activation and radical addition pathway.

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Cite This Study

Wen-ping et al. (2026) studied this question.

synapsesocial.com/papers/6a1d216202fbce9130637693https://doi.org/10.1021/acs.orglett.6c01979
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