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June 1, 2026Expert Review of Anticancer Therapy

Polypharmacy, polypharmacology, and polypharmacotherapy: clarifying definitions and complementary roles in cancer treatment – a narrative review

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Authors

AGAurora González‐FierroACAlma Chavez-BlancoGDGuadalupe Dominguez-Gomez

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Overview

Narrative review clarifies definitions and potential roles of polypharmacy in cancer treatment, suggesting complementary strategies.

Key Points

  • This review aims to clarify the concepts of polypharmacy, polypharmacology, and polypharmacotherapy and their roles in improving cancer treatment.
  • Examined definitions and implications of polypharmacy, polypharmacology, and polypharmacotherapy.
  • Discussed the importance of multi-target-directed ligands in drug design.
  • Identified urgent clinical trial needs to validate these approaches.
  • Polypharmacotherapy offers a pragmatic approach to complement precision oncology.
  • The current cancer drug development has a success rate of approximately 5.2%.
  • Median overall survival benefit from 124 FDA-approved drugs is only 2.8 months.

Cite This Study

González‐Fierro et al. (2026) studied this question.

synapsesocial.com/papers/6a1d22db02fbce91306388d9https://doi.org/10.1080/14737140.2026.2682866
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