Design, Formulation and Evaluation of Transdermal Patch of Diclofenac Sodium

The present study focuses on the design, formulation, and evaluation of a transdermal patch containing DICLOFENAC SODIUM, The aimed of this work to enhancing patient compliance, reducing gastrointestinal side effects, and providing sustained drug release. DICLOFENAC SODIUM, widely used for its analgesic, anti-inflammatory properties, typically suffers from low oral bioavailability and gastrointestinal irritation when administered orally. To address these issues, transdermal patches were formulated using the solvent evaporation technique, employing polymers such as HPMC and Guar gum, with methanol as the solvent and glycerine and Tween 80 as plasticizer and permeation enhancer, respectively. The prepared patches were evaluated for physical characteristics, drug content, pH, and uniformity. After this formulation and Evaluations, we are look that the patches were uniform, stable, and released the drug effectively over a 24-hour period. The study concludes that transdermal delivery of aspirin offers a promising alternative to oral administration, ensuring improved bioavailability and patient tolerance.