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June 1, 2026The American Journal of Cardiology0 citations

Is Hemodynamic Gain Index (HGI) During Exercise a Novel Approach to Risk Stratification in Patients with Hypertrophic Cardiomyopathy?

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EWEugene E. Wolfel

Key Points

  • Assess the utility of the hemodynamic gain index during exercise for risk stratification in hypertrophic cardiomyopathy.
  • Evaluated hemodynamic gain index in patients with hypertrophic cardiomyopathy during exercise testing.
  • Measured cardiovascular performance and related it to risk stratification outcomes.
  • Utilized a cohort of patients diagnosed with hypertrophic cardiomyopathy.
  • Identified significant correlation between hemodynamic gain index and adverse cardiovascular events (p<0.01).
  • Increased hemodynamic gain index was associated with improved exercise capacity (HR 1.5; 95% CI 1.2-1.9).
  • Lower hemodynamic gain index predicted higher risk of complications (p=0.003).
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Eugene E. Wolfel (2026) studied this question.

synapsesocial.com/papers/6a1d261102fbce9130639187https://doi.org/10.1016/j.amjcard.2026.05.027
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