Key points are not available for this paper at this time.
BACKGROUND: We investigated associations of neighborhood disadvantage with Alzheimer's Disease (AD)-related outcomes by biological and social factors in at-risk older adults. METHODS: 1,880 U.S. POINTER participants with Area Deprivation Index (ADI) and cognition (PACC) were included. 868 had amyloid, tau PET, white matter hyperintensities (WMH), and/or gray matter volumes. We conducted exploratory, linear models testing ADI interactions with sex, race and ethnicity, and APOE ε4, adjusting for age and education. RESULTS: "White/European American", "Hispanic/Latinx/Spanish" and "Others" showed lower cognitive scores with higher ADI, while "White/European American" showed the highest cognitive scores across ADI levels. APOE ε4 carriers from high-ADI areas showed higher WMH and tau, and "Hispanic/Latinx/Spanish" from more deprived areas showed higher WMH. Females from moderate-ADI areas showed higher tau. Amyloid burden was higher in APOE ε4 carriers from low-ADI areas. CONCLUSION: Differential associations of ADI with AD-related outcomes across biological and social factors may reflect systemic health disparities and study design.
Dominguez et al. (2026) studied this question.