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September 1, 1983Stroke

The incidence of stroke with permanent neurological deficit was twice as high in diabetics as in non-diabetics (p < .05), and three times higher in diabetic women (p < .02).

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Why the study?

Does diabetes increase the risk of stroke with permanent neurological deficit in patients with peripheral arterial disease?

Population

102 consecutive patients with peripheral arterial disease

Comparison

Diabetes vs Non-diabetics with equivalent atherosclerotic…

Design

Cohort

Authors

JWJesse WeinbergerVBVictoria BiscarraMWMichael Weisberg

Discussion

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Overview

May signal greater disabling stroke risk in diabetic PAD patients, especially women; leaves open causal mechanisms and targeted prevention needs.

Key Points

  • This research aims to assess the role of diabetes in the incidence of stroke among patients with atherosclerotic disease.
  • Analyzed 102 consecutive patients with peripheral arterial disease to identify incidence of carotid artery disease and cerebrovascular symptoms.
  • Correlated symptoms with risk factors including age, hypertension, smoking, and diabetes.
  • Compared stroke incidence between diabetics and non-diabetics with equivalent atherosclerotic vascular disease.
  • Diabetics had a stroke incidence with permanent neurological deficit that was twice as high as non-diabetics (p < .05).
  • Among women, stroke incidence was three times higher in diabetics compared to non-diabetics (p < .02).
  • The total number of ischemic episodes was equivalent in both groups, suggesting diabetes leads to more severe brain tissue damage.

Structured PICO

Does diabetes increase the risk of stroke with permanent neurological deficit in patients with peripheral arterial disease?

P
Population
102 consecutive patients with peripheral arterial disease
I
Intervention
Diabetes
C
Comparator
Non-diabetics with equivalent atherosclerotic vascular disease
O
Outcome
Incidence of stroke with permanent neurological deficithard clinical

Diabetic patients with peripheral arterial disease are more prone to irreversible ischemic brain tissue damage (stroke) compared to non-diabetics, despite having an equivalent total number of ischemic episodes.

Cite This Study

Weinberger et al. (1983) studied this question.

synapsesocial.com/papers/6a1d2a251c2cbcb15c5ddf75https://doi.org/10.1161/01.str.14.5.709
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