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Abstract Patients with diabetes often grapple with impaired wound healing, which can lead to amputations or even fatal outcomes. Bacterial biofilms, protected by extracellular polymeric substances, pose a significant barrier to antibacterial treatments. Hyperglycemia perpetuates inflammation, further complicating chronic wounds. To tackle this issue, a multifunctional nanocomposite (CuO 2 ‐ICG NPs) with acid‐degradable properties is developed. Within biofilms, they release copper ions (Cu 2+ ), hydrogen peroxide (H 2 O 2 ), and indocyanine green (ICG), initiating neutrophil‐mimicking reactions and photodynamic actions. This generates hypochlorous acid (HClO) and singlet oxygen ( 1 O 2 ), effectively degrading the biofilm and eradicating bacteria, reducing the viability of Pseudomonas aeruginosa and Staphylococcus aureus by 6.85 log 10 and 9.00 log 10 , respectively. In addition, CuO 2 ‐ICG NPs demonstrate anti‐inflammatory properties, preventing M1 macrophage polarization and chronic inflammation. They also accelerate wound healing by stimulating angiogenesis and fibroblast migration. In diabetic mice with biofilm‐infected wounds, CuO 2 ‐ICG NPs significantly shorten the healing time. This groundbreaking discovery offers promising new avenues for therapeutic approaches in diabetic wound management.
Liu et al. (2025) studied this question.