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November 16, 2017PLoS ONE15 citationsOpen Access

Which patients recur as atrial tachycardia rather than atrial fibrillation after catheter ablation of atrial fibrillation?

PYPil‐Sung YangYPYoungAh ParkTKTae‐Hoon Kim

Key Result

Less left atrial remodeling, indicated by high mean left atrial bipolar voltage (OR 2.03) and small left atrial volume index, was independently associated with recurrence as atrial tachycardia rather than atrial fibrillation after catheter ablation.

Study Design

Type

Cohort (n=521)

Multicenter

No

Structured PICO

Does the degree of left atrial remodeling predict recurrence as atrial tachycardia rather than atrial fibrillation in patients undergoing catheter ablation for atrial fibrillation?

P
Population
521 patients (70.8% men, 64.1% paroxysmal AF) who experienced atrial tachycardia (AT) or atrial fibrillation (AF) recurrence without antiarrhythmic drug effect after de novo radiofrequency catheter ablation for AF. Mean age 59.3 years.
I
Intervention
Radiofrequency catheter ablation for AF (circumferential pulmonary vein isolation and cavotricuspid isthmus ablation, with or without additional linear ablation or complex fractionated electrogram-guided ablation)
C
Comparator
Patients recurring with atrial fibrillation (AF) vs. patients recurring with atrial tachycardia (AT)
O
Outcome
Recurrence as atrial tachycardia (AT) rather than atrial fibrillation (AF) during follow-up

Less left atrial structural and electrical remodeling (smaller volume, higher voltage) is associated with recurrence as atrial tachycardia rather than atrial fibrillation after AF ablation, independent of linear ablation gaps.

Main Result

Effect estimate: OR 2.03 (95% CI 1.30-3.16)

p-value: p=0.002

Limitations

  • Retrospective observational design
  • Ablation lesion set differed between patients with paroxysmal AF and those with persistent AF
  • Bidirectional block rates of de novo linear ablations were relatively lower compared to previous reports
  • A relatively small proportion of patients with recurrence underwent redo ablation
  • Analyzed both early and late recurrence together
  • Left atrial bipolar voltage maps were analyzable in only 68.1% of included patients

Abstract

INTRODUCTION: The ablation gaps have been known as the main mechanism of recurrence as atrial tachycardia (AT) rather than atrial fibrillation (AF) after AF catheter ablation. However, AF organization due to reduction of critical mass or focal trigger may also be the mechanism of AT recurrence. We sought to find out the main clinical factors of recurrence as AT rather than AF after AF ablation in the absence of antiarrhythmic drug effect. METHODS: We analyzed 521 patients (70.8% men, 64.1% paroxysmal AF) who experienced AT or AF recurrence without antiarrhythmic drug effect during 44.7 ± 25.4 months follow-up. RESULTS: Among 521 patients with recurrence, 42.0% (219 of 521) recurred with AT. The proportion of AT recurrence was not different between the pulmonary vein isolation only group and additional linear ablation group (45.1% vs. 38.1%, p = 0.128). The absence of hypertension (odds ratio OR 0.49, 95% confidence interval CI 0.29-0.83, p = 0.007), small left atrial (LA) volume index (OR 0.89 per 10 mL/m2, 95% CI 0.79-1.00, p = 0.049), and high mean LA bipolar voltage (OR 2.03 per 1 mV, 95% CI 1.30-3.16, p = 0.002) were independently associated with AT recurrence, whereas additional linear ablation was not. Among 90 patients who underwent repeat ablation procedure, rates of PV reconnection (p = 0.358) and gap in prior linear ablations (p = 0.269) were not significantly different between AT recurrence group and AF recurrence group. CONCLUSION: The degree of LA remodeling is significantly associated with recurrence as AT after AF ablation, irrespective of potential ablation gap in linear lesion.

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Cite This Study

Yang et al. (2017) conducted a cohort in Atrial fibrillation recurrence after catheter ablation (n=521). High mean left atrial bipolar voltage (per 1 mV) vs. Low mean left atrial bipolar voltage was evaluated on Recurrence as atrial tachycardia (AT) rather than atrial fibrillation (AF) (OR 2.03, 95% CI 1.30-3.16, p=0.002). Less left atrial remodeling, indicated by high mean left atrial bipolar voltage (OR 2.03) and small left atrial volume index, was independently associated with recurrence as atrial tachycardia rather than atrial fibrillation after catheter ablation.

synapsesocial.com/papers/6a1d755073c56dd1bd2fb59fhttps://doi.org/10.1371/journal.pone.0188326
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-Term Outcome After Successful Catheter Ablation of Atrial Fibrillation2010 · 239 citations
  2. 2Atrial Tachycardias Encountered during and after Catheter Ablation for Atrial Fibrillation: Part I: Classification, Incidence, Management2009 · 44 citations
  3. 3Atrial Tachycardia After Ablation of Persistent Atrial Fibrillation2008 · 140 citations
  4. 4Significant Reduction of Atrial Defibrillation Threshold and Inducibility by Catheter Ablation of Atrial Fibrillation2012 · 24 citations
  5. 5The Relationship Between Endocardial Voltage and Regional Volume in Electroanatomical Remodeled Left Atria in Patients with Atrial Fibrillation: Comparison of Three‐Dimensional Computed Tomographic Images and Voltage Mapping2009 · 61 citations