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July 23, 2025Frontiers in Physiology2 citationsOpen Access

Association between heart rate variability and ECG changes in on-duty prehospital physicians

MMMathias MaleczekKSKarl SchebestaTHThomas Hamp

Key Result

Higher SDNN values were significantly associated with an increased probability of immediate ST-T abnormalities (OR 1.04) in on-duty prehospital emergency physicians.

Study Design

Type

Observational (n=20)

Multicenter

No

Structured PICO

Is heart rate variability associated with ST-T segment changes in on-duty prehospital emergency physicians?

P
Population
20 prehospital emergency physicians, mean age 39, 40% female.
I
Intervention
Heart rate variability (HRV) metrics (SDNN, RMSSD, pNN50) monitoring
O
Outcome
Association of different HRV metrics with immediate ST-T abnormalitiessurrogate

HRV metrics alone do not reliably correlate with ST-T segment changes during stressful missions in prehospital emergency physicians, indicating that HRV cannot replace 12-lead ECG for detecting stress-related cardiac alterations.

Main Result

Effect estimate: OR 1.04 (95% CI 1.03-1.04)

Limitations

  • Retrospective analysis subject to selection and analytical bias
  • Reliance on automated software for HRV computation introduces a potential source of systematic error
  • Use of a 5-min interval for both metrics may not capture all dynamics
  • T-wave inversions are clinically ambiguous and must be interpreted with caution in the absence of concurrent clinical symptoms
  • Reliance on automated software for HRV computation
  • 5-min interval used for both metrics
  • Clinical ambiguity of T-wave inversions

Abstract

Background/objectives: Prehospital emergency physicians work in physically and psychologically stressful environments. During their shifts, changes in electrocardiogram (ECG) attributable to stress have been described previously. Alterations in heart rate variability (HRV) as well as in ST-T segments have been reported. Nevertheless, the association between those two parameters still remains unclear in this setting. Methods: A retrospective analysis of data collected in a previous prospective trial was conducted. The primary objective was the association of HRV metrics with the risk of ST-T abnormalities during 5-min intervals and on a mission basis. Therefore, the root mean square of successive differences (RMSSD) and standard deviation of normal-to-normal (SDNN) intervals were analysed. Additionally, variations in HRV during different phases of a mission were investigated. Results: Data of 20 physicians was analysed. SDNN was positively associated with ST-T abnormalities both on a 5 min basis (OR: 1.04, 95%CI: 1.03-1.04) and a mission basis while RMSSD was negatively associated with ST-T abnormalities evaluated per mission (OR: 0.73, 95%CI: 0.57-0.93). pNN50 was not associated with ST-T abnormalities. During patient care and patient transport HRV was significantly lower than during alarm and en-route of a rescue mission. Conclusion: No reliable correlation between HRV values and the occurrence of ST-T segment changes during missions in prehospital emergency physicians were found. Therefore, it is questionable whether HRV alone is sufficient to detect ischemia-like changes during stressful events.

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Cite This Study

Maleczek et al. (2025) conducted an observational in Occupational stress in prehospital emergency physicians (n=20). Heart rate variability (HRV) monitoring was evaluated on Association of SDNN with immediate ST-T abnormalities (5-min intervals) (OR 1.04, 95% CI 1.03-1.04). Higher SDNN values were significantly associated with an increased probability of immediate ST-T abnormalities (OR 1.04) in on-duty prehospital emergency physicians.

synapsesocial.com/papers/6a1d81b173c56dd1bd2fc608https://doi.org/10.3389/fphys.2025.1617377
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