Young adults with type 1 diabetes exhibited reduced baseline transcutaneous tissue oxygenation (37.5 vs. 49.5 mmHg) and altered Valsalva hemodynamics compared to healthy controls.
Cross-Sectional (n=30)
Open-label
No
Do young adults with Type 1 Diabetes exhibit altered microcirculatory function and cardiovascular autonomic reflexes compared to non-diabetic controls?
Young adults with T1D exhibit reduced tissue oxygenation and altered Valsalva hemodynamics despite preserved standard autonomic reflex functions, indicating early microcirculatory changes.
Absolute Event Rate: 37.5% vs 49.5%
p-value: p=0.034
AimsCardiac autonomic neuropathy is currently an untreatable progressive complication of type 1 diabetes (T1D).Impaired microcirculation is a suspected cause of nerve degeneration in TID.We investigated whether cardiovascular autonomic reflexes often used as indices of nerve functions, are associated with indices of microcirculatory function in young adults with T1D compared with non-diabetic controls. MethodsIn a cross-sectional study, 15 adults with T1D and 15 age-matched controls (20-40 years) underwent standardized cardiovascular autonomic reflex tests.Continuous recordings of electrocardiogram, cardiac vagal tone, beat-to-beat blood pressure and transcutaneous tissue oxygen (tcpO₂) and carbon dioxide partial pressures (tcpCO 2 ) were done. ResultsDespite preserved baroreflex, parasympathetic, and sympathetic functions assessed using cardiovascular reflex tests, the individuals with T1D exhibited reduced baseline tcpO 2 compared to the controls (37.5±3.75 vs. mmHg). During theValsalva manoeuvre, individuals with T1D exhibited a reduced systolic blood pressure response in phase I (31±10 vs. 43±18 mmHg) and early phase II (-1±15 vs. -18±17 mmHg), and an increased systolic (31±15 vs. 18±14 mmHg) and diastolic (45±11 vs. 33±16 mmHg) response in late phase II compared to controls.The early phase II diastolic response was inversely associated with baseline tcpO 2 .
Maria et al. (2026) conducted a cross-sectional in Type 1 Diabetes (n=30). Type 1 Diabetes vs. Healthy non-diabetic controls was evaluated on Baseline transcutaneous tissue oxygenation (tcpO2) (p=0.034). Young adults with type 1 diabetes exhibited reduced baseline transcutaneous tissue oxygenation (37.5 vs. 49.5 mmHg) and altered Valsalva hemodynamics compared to healthy controls.