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March 1, 2012Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology24 citations

Evaluation of subclinical left ventricular systolic dysfunction in patients with obstructive sleep apnea by automated function imaging method; an observational study

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Why the study?

Does automated function imaging detect subclinical left ventricular systolic dysfunction in patients with obstructive sleep apnea and normal LVEF?

Population

79 individuals

Comparison

Automated function imaging method based on… vs Healthy individuals and comparison across OSA…

Design

Cross-sectional

Key result

Obstructive sleep apnea severity was associated with progressively decreased global longitudinal strain compared to healthy individuals (Healthy: -25.58% vs Severe OSA: -16.94%, p<0.03).

Authors

RARefik Emre AltekinAYAtakan YanıkoğluMKMustafa Serkan Karakaş

Discussion

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Overview

Supports subclinical LV dysfunction detection by automated imaging in OSA despite normal LVEF; leaves open outcome impact.

Study Design

Type

Cross-Sectional (n=79)

Multicenter

No

Structured PICO

Does automated function imaging detect subclinical left ventricular systolic dysfunction in patients with obstructive sleep apnea and normal LVEF?

P
Population
79 adults aged 30-60 years with normal left ventricular ejection fraction, including 58 with obstructive sleep apnea and 21 healthy controls, evaluated for subclinical left ventricular systolic dysfunction.
E
Exposure
Automated function imaging method (AFI) based on speckle tracking echocardiography (STE)
C
Comparator
Healthy individuals and comparison across OSA severity groups (mild, moderate, severe)
O
Outcome
Global systolic longitudinal strain (GLS) valuessurrogate

Automated function imaging demonstrates that longitudinal left ventricular mechanics deteriorate in proportion to disease severity in patients with obstructive sleep apnea despite normal LVEF.

Main Result

Absolute Event Rate: -16.94% vs -25.58%

p-value: p=<0.03

Limitations

  • Used Epworth and Berlin scale methods rather than AHI for selection of healthy controls
  • Could not assess the effects of possible increased blood pressure during sleeping induced by apnea/hypopnea episodes
  • BMI was significantly higher in the severe OSA group compared to the healthy group
  • Circumferential and radial LV functions could not be assessed due to technical limitations of the AFI method
  • Small sample size limits the evaluation of the method's efficacy
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Cite This Study

Altekin et al. (2012) conducted a cross-sectional in Obstructive sleep apnea (n=79). Obstructive sleep apnea vs. Healthy individuals was evaluated on Global systolic longitudinal strain (GLS) (p=<0.03). Obstructive sleep apnea severity was associated with progressively decreased global longitudinal strain compared to healthy individuals (Healthy: -25.58% vs Severe OSA: -16.94%, p<0.03).

synapsesocial.com/papers/6a1ed08deed4f0c78fa446e9https://doi.org/10.5152/akd.2012.096
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