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October 1, 1912The Journal of Experimental Medicine46 citationsOpen Access

Fibrillation of the Auricles: Its Effects Upon the Circulation

TLThomas LewisRoyal National Orthopaedic Hospital

Key Result

Fibrillation of the auricles causes passive peripheral circulatory effects, including changes in arterial and venous pressure, attributable to alterations in the rate of ventricular contraction.

Key Points

  • This study aims to explore the effects of auricular fibrillation on circulation and hemodynamics.
  • Detailed observations of arterial and venous blood pressure changes were conducted during auricular fibrillation.
  • The relationship between intestinal volume, cardiac output, and arterial blood pressure was analyzed.
  • Arterial blood pressure typically falls during fibrillation but may return to initial levels.
  • Venous pressure changes are opposite to those of arterial pressure.
  • Cardiac output changes correlate with arterial blood pressure.

Structured PICO

What are the circulatory effects of auricular fibrillation?

P
Population
Not explicitly stated in abstract (likely animal model given measurements of intestinal volume and induction shocks)
E
Exposure
Induction of auricular (atrial) fibrillation
C
Comparator
Regular induction shocks causing similar heart rate acceleration
O
Outcome
Circulatory effects including arterial blood pressure, venous pressure, intestinal volume, cardiac output, and heart volumesurrogate

The peripheral circulatory effects of auricular fibrillation are purely passive and driven by changes in ventricular contraction rate.

Abstract

When the auricles fibrillate, the following effects are observed. 1. The arterial blood pressure may rise, fall, or remain stationary. Usually it falls. If it falls, it generally rises again towards or to the initial pressure. 2. The venous pressure changes are the reverse of the arterial. 3. The intestinal volume and the cardiac output changes are in the same direction as those of arterial blood pressure. 4. From these observations it may be concluded that the peripheral circulatory effects are purely passive. 5. The volume of the heart decreases except in instances where there is reason to believe that the circulation is failing. All the changes described in the foregoing paragraphs, and also the variations in blood pressure reactions which occur from time to time, are attributable to alterations in the rate of ventricular contraction. Similar, though perhaps less profound changes, are seen when the heart rate accelerates in like degree in response to regular induction shocks.

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Cite This Study

Thomas Lewis (1912) studied Fibrillation of the auricles. Fibrillation of the auricles was evaluated on Circulatory effects (arterial blood pressure, venous pressure, intestinal volume, cardiac output, heart volume). Fibrillation of the auricles causes passive peripheral circulatory effects, including changes in arterial and venous pressure, attributable to alterations in the rate of ventricular contraction.

synapsesocial.com/papers/6a1efca716ec2d13766b608ehttps://doi.org/10.1084/jem.16.4.395
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