Why the study?
Does higher heparin dosage reduce acute platelet-thrombus deposition after arterial angioplasty in a porcine model?
Population
32 normal pigs (mean weight, 32.7 kg) undergoing bilateral carotid angioplasty
Comparison
Higher dose heparin regimens: Protocol 2 or… vs Protocol 1: single intravenous bolus injection…
Design
Preclinical
Follow-up
90 +/- 26 minutes
Key result
In a porcine angioplasty model, platelet deposition on injured arteries was 86.3, 56.2, and 37.7 x 10^6/cm2 for single bolus, double bolus, and bolus plus infusion heparin regimens, respectively.
Authors
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Sustained heparin regimens may attenuate platelet deposition post-injury; hypothesis-generating for human angioplasty dosing.
Does higher heparin dosage reduce acute platelet-thrombus deposition after arterial angioplasty in a porcine model?
Higher and sustained heparin dosing regimens appear to reduce acute platelet deposition following arterial injury in a porcine angioplasty model.
Heras et al. (1988) studied Arterial angioplasty (n=32). Heparin vs. Different heparin regimens was evaluated on 111In-labeled platelet deposition on deeply injured arterial segments. In a porcine angioplasty model, platelet deposition on injured arteries was 86.3, 56.2, and 37.7 x 10^6/cm2 for single bolus, double bolus, and bolus plus infusion heparin regimens, respectively.