Population
Isolated dog heart, perfused with blood from an anesthetized donor
Comparison
Isovolumic contraction or ejecting saline vs Isobaric loading
Design
Preclinical
Key result
In isolated dog hearts, the efflux of norepinephrine was directly related to the systolic pressure of the left ventricle, suggesting a pathway where high systolic pressure may deplete norepinephrine.
Authors
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No immediate clinical implications; leaves open a pressure-dependent norepinephrine depletion pathway for human validation.
In an isolated dog heart model, norepinephrine efflux is directly related to left ventricular systolic pressure, providing a potential mechanism for myocardial norepinephrine depletion under high pressure loads.
MONROE et al. (1966) studied this question. Isovolumic loading and systolic pressure variations vs. Ejecting saline / isobaric loading was evaluated on Norepinephrine efflux and ventricular performance. In isolated dog hearts, the efflux of norepinephrine was directly related to the systolic pressure of the left ventricle, suggesting a pathway where high systolic pressure may deplete norepinephrine.