Increased baseline arterial stiffness was significantly associated with new onset of hypertension (OR up to 3.28; P<0.001), but not with new onset of diabetes.
Observational (n=3,960)
Is increased arterial stiffness associated with the development of hypertension independently of diabetes in middle-aged adults?
Increased arterial stiffness is bidirectionally associated with the development of hypertension, but not diabetes, in middle-aged adults.
Odds Ratio: 3.28
p-value: p=<0.001
Background Hypertension and diabetes frequently coexist; however, it has not yet been clarified if the bidirectional longitudinal relationships between arterial stiffness and hypertension are independent of those between arterial stiffness and diabetes. Methods and Results In this 16‐year prospective observational study, 3960 middle‐aged employees of a Japanese company without hypertension/diabetes at the study baseline underwent annual repeated measurements of blood pressure, serum glycosylated hemoglobin A 1c levels, and brachial‐ankle pulse wave velocity. By the end of the study period, 664, 779, 154, and 406 subjects developed hypertension, prehypertension, diabetes, and prediabetes, respectively. Increased brachial‐ankle pulse wave velocity at the baseline was associated with a significant odds ratio (per 1 SD increase) for new onset of prehypertension/hypertension with (2.45/3.28; P <0.001) or without (2.49/2.76; P <0.001) coexisting prediabetes/diabetes, but not for new onset of prediabetes/diabetes without coexisting hypertension. Analyses using the latent growth curve model confirmed the bidirectional relationships between brachial‐ankle pulse wave velocity and hypertension, but no such relationship was observed between brachial‐ankle pulse wave velocity and abnormal glucose metabolism. Conclusions In middle‐aged employees of a Japanese company, while bidirectional relationships were found to exist between increased arterial stiffness and hypertension, such a relationship was not found between increased arterial stiffness and diabetes. Therefore, it appears that increased arterial stiffness may be associated with the development of hypertension but not with that of diabetes.
Nakano et al. (2022) conducted an observational in Without hypertension or diabetes (n=3,960). Increased brachial-ankle pulse wave velocity was evaluated on New onset of prehypertension/hypertension (OR 3.28, p=<0.001). Increased baseline arterial stiffness was significantly associated with new onset of hypertension (OR up to 3.28; P<0.001), but not with new onset of diabetes.