PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
June 3, 2026RSC Chemical Biology0 citationsOpen Access

Synthesis and characterization of a novel phosphatidylinositol 5-phosphate (PI(5)P) photoaffinity probe

GBGlen BrodieASAhmed SayedSKSarah Kreuz

Key Points

  • The aim is to develop and characterize a new photoaffinity probe for PI(5)P binding proteins.
  • Synthesis of a novel PI(5)P photoaffinity probe.
  • Characterization involved copper-catalyzed alkyne-azide click reactions.
  • Used known PI(5)P binding proteins hUHRF1 and hTAF3 with dyes and affinity tags.
  • Successfully synthesized and characterized the PI(5)P photoaffinity probe.
  • Demonstrated interactions with binding proteins hUHRF1 and hTAF3 through labeled reactions.

Abstract

A novel PI(5)P photoaffinity probe was synthesized. The probe was characterized in copper-catalyzed alkyne-azide click reactions with the known PI(5)P nuclear binding proteins hUHRF1 and hTAF3 using dyes and affinity tags.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Brodie et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc42cdee9eb8c0dce5cd7https://doi.org/10.1039/d6cb00148c
Ask AI
Helpful
Bookmark
Share
View Full Paper