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June 3, 2026Food Science and Human WellnessOpen Access

Fucoidan from Saccharina japonica attenuates hyperuricemia in mice via modulation of gut microbiota and uric acid metabolism

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Authors

WMWenya Meng张Z张静 Jing ZHANGYCYiming Chen

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Overview

Randomized trial reveals fucoidan lowers uric acid levels in mice, suggesting its potential as a dietary supplement.

Key Points

  • This research aims to explore how fucoidan affects uric acid metabolism and gut health in hyperuricemic mice.
  • HUA mouse model induced by a high-purine diet and potassium oxonate.
  • Ultra performance liquid chromatography analysis to identify fucoidan composition.
  • 16S rRNA sequencing and targeted metabolomics to analyze gut microbiota changes.
  • Fucoidan significantly reduced serum uric acid levels and ameliorated renal inflammation and injury.
  • FC administration increased beneficial bacteria and decreased harmful bacteria in the gut microbiota.
  • Fucoidan reversed the reduction in short-chain fatty acid levels caused by hyperuricemia.

Cite This Study

Meng et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc58bdee9eb8c0dce6fe3https://doi.org/10.26599/fshw.2026.9250990
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