Central systolic blood pressure exceeded peripheral systolic blood pressure in 40.4% of subjects, while central diastolic blood pressure exceeded peripheral diastolic blood pressure in 50.4%.
Cross-Sectional (n=240)
What clinical factors influence the variations between peripheral and central 24-hour ambulatory blood pressure measurements?
Approximately half of subjects exhibited higher central blood pressure compared to peripheral blood pressure, with variations influenced by office diastolic blood pressure, uncontrolled BP status, resting heart rate, and antihypertensive medication dose.
Objective: To examine the determinants associated with elevated central blood pressure (cBP) relative to peripheral blood pressure (pBP). Design and method: Data derived from Siriraj Ambulatory Monitoring of Blood Pressure (SiAM-BP) registry were collected during 2019 - 2025 within this cross-sectional study. To be eligible for inclusion, 24-hour ambulatory blood pressure (ABPM) records had to provide both pBP and cBP values, with a minimum requirement of 20 valid daytime readings and 7 valid nighttime readings. The participants were categorized into two groups based on the discrepancy between their 24-hour peripheral and central blood pressure: those with peripheral BP exceeding central BP, and those exhibiting central BP higher than peripheral BP. The baseline characteristics and basic laboratory results were collected. Results: From the initial screening of 242 subjects’ ABPM records, two cases were not met the criteria for valid nighttime blood pressure records. This resulted in a final sample size of 240 for data analysis. Mean age was 51.9 + 16.7 years. Fifty-three percent of them were men. The proportion of previous diagnosed hypertension, diabetes mellitus, and dyslipidemia were 77.3%, 12.6%, and 64%, respectively. The overall mean 24-hour pBP was 126.6 + 14.6/ 76.7 + 10.9 mmHg, whereas the overall mean 24-hour cBP was 123.8 + 13.1/ 75.2 + 12.6 mmHg. The proportion of individuals whose central systolic BP (cSBP) exceeded their peripheral SBP (pSBP) accounted for 40.4% (97 ABPM records). However, 50.4% of them exhibited higher central diastolic BP (cDBP) than their peripheral DBP (pDBP). Multivariable analysis adjusted by mean 24-hour mean arterial pressure and heart rate showed that office pDBP and uncontrolled BP status were independently positive associated factors of the condition of cSBP surpassing pSBP. Office resting heart rate and total dose of antihypertensive medications were inversely associated factors of this condition. Conversely, office pDBP and uncontrolled BP status negatively associated with the condition of cDBP surpassing pDBP. Conclusions: Approximately half of the all subjects exhibited higher cBP compared to pBP. The factors influencing this condition varied depending on whether SBP or DBP was being considered.
Chotruangnapa et al. (2026) conducted a cross-sectional in Hypertension (n=240). Clinical factors (office diastolic BP, uncontrolled BP status, resting heart rate, antihypertensive medications) was evaluated on Central blood pressure exceeding peripheral blood pressure. Central systolic blood pressure exceeded peripheral systolic blood pressure in 40.4% of subjects, while central diastolic blood pressure exceeded peripheral diastolic blood pressure in 50.4%.