Cross-sectional study analyzes anxiety in Alzheimer's, highlighting ALFF as a potential biomarker.
Key Points
The study aims to characterize neural correlates of anxiety in Alzheimer's disease using ALFF analysis.
Cross-sectional study with 54 participants categorized into AD patients with anxiety, without anxiety, and healthy controls.
Cognitive and anxiety symptoms assessed using MMSE and HAMA, followed by fMRI scanning to calculate ALFF values.
Statistical analysis performed using Kruskal-Wallis tests for group comparisons.
HCs had significantly higher MMSE scores than both AD groups.
HAMA scores were significantly higher in the AD-A group compared to the AD-nA group.
AD-A group exhibited decreased ALFF in the left insula and anterior cingulate cortex compared to AD-nA, while showing decreased ALFF in the right fusiform gyrus relative to HCs.