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Synapse
June 3, 2026Open Access

Minor neuropsychological deficits and stage 2 of Alzheimer's disease.

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Authors

MSMelina StarkMWMichael WagnerEKElizabeth Kuhn

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Overview

Randomized trial shows risk for mild cognitive impairment in cognitively normal individuals, suggesting improved diagnosis methods.

Key Points

  • This research aims to understand the role of subtle cognitive symptoms in predicting Alzheimer’s disease progression.
  • Pooled data from 13,192 cognitively normal individuals across three longitudinal cohort studies.
  • Participants categorized into four groups based on subjective cognitive decline (SCD) and minor neuropsychological deficits (MNPD).
  • Analyzed the association between SCD/MNPD and the risk of mild cognitive impairment (MCI) and dementia.
  • Participants with SCD-/MNPD+ and SCD+/MNPD+ showed an increased risk for MCI and dementia compared to those without SCD and MNPD.
  • Focus on SCD+/MNPD+ increased the positive predictive value of amyloid biomarker testing for MCI prediction by three times.
  • Sample size for clinical trials in preclinical AD can be reduced to one-fourth when considering SCD and MNPD.

Cite This Study

Stark et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc696dee9eb8c0dce78echttps://doi.org/10.48620/98241
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