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June 3, 2026Journal of Hypertension

High residual platelet reactivity and higher systolic BP predict repeat PCI in ischemic post-CABG patients.

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Why the study?

The study was conducted to assess the prognostic impact of arterial hypertension and high residual platelet reactivity on the need for repeat PCI in patients with recurrent ischemia after CABG.

Do arterial hypertension and high residual platelet reactivity predict the need for repeat PCI in post-CABG patients with recurrent ischemia?

Population

195 post-CABG adults with stable CAD and recurrent ischemic symptoms 6-36 months post-surgery

Comparison

Need for repeat PCI vs no revascularization

Design

Observational, single-center, cross-sectional study

Key result

High residual platelet reactivity (66.2% vs 0%, p<0.001) and higher systolic blood pressure independently predicted the need for repeat PCI in post-CABG patients with recurrent ischemia.

Authors

ШЖШ.Б. ЖангеловаДКДина КапсултановаFNFriba Nurmukhammad

Discussion

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Member takes

Overview

Should not yet change practice in post-CABG recurrent ischemia; leaves open whether targeting SBP or platelet reactivity reduces repeat PCI.

Key Points

  • This study aims to evaluate how arterial hypertension and high residual platelet reactivity influence repeat interventions in patients experiencing recurrent ischemia after CABG.
  • Observational, single-center, cross-sectional study with 195 adults having CABG and recurrent ischemia
  • Patients underwent clinical, biochemical, and echocardiographic assessments along with HRPR measurement using VerifyNow P2Y12 assay
  • Predictors of re-intervention were analyzed using statistical methods including Mann-Whitney, chi-square, and logistic regression.
  • Repeat PCI was necessary for 136 patients (69.7%) with significant predictors including older age, higher blood pressure, and HRPR
  • Systolic blood pressure was higher in the repeat PCI group (130 mmHg vs 120 mmHg, p=0.041)
  • HRPR was present in 66.2% of those needing repeat PCI (p<0.001).

Study Design

Type

Cross-Sectional (n=195)

Multicenter

No

Structured PICO

Do arterial hypertension and high residual platelet reactivity predict the need for repeat PCI in post-CABG patients with recurrent ischemia?

P
Population
195 adults with stable coronary artery disease and recurrent ischemic symptoms 6-36 months post-CABG, evaluated for predictors of repeat PCI.
E
Exposure
Arterial hypertension and high residual platelet reactivity (HRPR, PRU≥208)
O
Outcome
Need for repeat percutaneous coronary intervention (PCI)hard clinical

Main Result

p-value: p=<0.001

Elevated systolic blood pressure and high residual platelet reactivity are strong independent predictors of the need for repeat PCI in post-CABG patients presenting with recurrent ischemia.

Limitations

  • single-center

Cite This Study

Жангелова et al. (2026) conducted a cross-sectional in Recurrent ischemia after coronary artery bypass grafting (CABG) (n=195). Arterial hypertension and high residual platelet reactivity vs. Normal blood pressure and normal platelet reactivity was evaluated on Need for repeat percutaneous coronary intervention (PCI) (p=<0.001). High residual platelet reactivity (66.2% vs 0%, p<0.001) and higher systolic blood pressure independently predicted the need for repeat PCI in post-CABG patients with recurrent ischemia.

synapsesocial.com/papers/6a1fc6cddee9eb8c0dce7bf8https://doi.org/10.1097/01.hjh.0001196760.17509.f6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Residual Platelet Reactivity and Dyslipidemia in Post-CABG Patients Undergoing Repeat Revascularization: Insights from Kazakhstan2025
  2. 2High Residual Platelet Reactivity After Clopidogrel Loading and Long-term Cardiovascular Events Among Patients With Acute Coronary Syndromes Undergoing PCI2011 · 404 citations
  3. 3Evaluation of Clinical Risk Factors to Predict High On-Treatment Platelet Reactivity and Outcome in Patients with Stable Coronary Artery Disease (PREDICT-STABLE)2015 · 40 citations
  4. 4Clinical impact of high platelet reactivity in patients with atrial fibrillation and concomitant percutaneous coronary intervention on dual or triple antithrombotic therapy2023 · 2 citations
  5. 5Predictors of recurrent angina in patients with no need for secondary revascularization2020 · 2 citations