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June 3, 2026Cureus0 citationsOpen Access

Atypical Hemolytic Uremic Syndrome Presenting with Diffuse Alveolar Hemorrhage: A Rare Extra-Renal Manifestation

SMShilpa MandalMPMekhala PaulGBGourab Bhaduri

Key Points

  • To report the rare presentation of diffuse alveolar hemorrhage in a patient with atypical hemolytic uremic syndrome and chronic kidney disease.
  • Case presentation of a 72-year-old male with chronic kidney disease.
  • Diagnosis of atypical hemolytic uremic syndrome through clinical workup.
  • Treatment involved plasmapheresis and corticosteroid therapy.
  • Patient responded positively to therapy.
  • Prompt diagnosis and multidisciplinary management were crucial in addressing the atypical presentation.

Abstract

We report the case of a 72-year-old male patient with chronic kidney disease (CKD) who presented with diarrhea and subsequently developed thrombotic microangiopathy (TMA) and diffuse alveolar hemorrhage (DAH). Diagnostic workup and clinical course led to a final diagnosis of atypical hemolytic uremic syndrome (aHUS). The patient responded to plasmapheresis and corticosteroid therapy. This case highlights a rare presentation of aHUS with DAH in a patient with pre-existing CKD, and the importance of prompt recognition and multidisciplinary management.

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Cite This Study

Mandal et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc718dee9eb8c0dce7e65https://doi.org/10.7759/cureus.110039
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