Background The Triglyceride-Glucose Index (TyG) has emerged as a convenient surrogate marker of insulin resistance and has been linked to various metabolic disorders. However, its relationship with Acute Pancreatitis (AP) in adult critically ill patients remains unclear. Methods The authors analyzed 2,588 adult critically ill patients from the MIMIC database. Participants were stratified by median TyG and TyG-BMI indices. Logistic regression, restricted cubic spline, and subgroup analyses evaluated associations with AP risk. ROC curves assessed predictive performance. Results High TyG and TyG-BMI groups exhibited greater metabolic derangements, longer ICU/hospital stays, and higher comorbidity burden. AP patients (9.4%) had elevated TyG levels (9.9 vs. 8.7, p < 0.001). Both indices were independently associated with AP risk in continuous, IQR, and quartile analyses (TyG: OR per IQR = 2.08, 95% CI 1.75–2.48; TyG-BMI: OR per IQR = 1.34, 95% CI 1.12–1.58). TyG showed linear dose-response, whereas TyG-BMI exhibited nonlinear associations. Associations were consistent across subgroups. ROC analysis indicated superior predictive ability for TyG (AUC = 0.809) versus TyG-BMI (AUC = 0.787, p = 0.00227). Conclusion Both TyG and TyG‑BMI indices are independent predictors of acute pancreatitis, with TyG demonstrating a statistically higher but modestly improved discriminative performance.
Luo et al. (2026) studied this question.