Viral genetic determinants play a lesser role in BKPyV replication and clinical consequences compared to host-related factors like older age in kidney transplant recipients.
Do BKPyV genomic features underlie clinical divergence between kidney and hematopoietic transplant recipients?
Host-related factors, such as age, appear to be more important than viral genetic determinants in driving the clinical consequences of BKPyV replication in transplant recipients.
< 0.0001). In KTRs, patients with presumptive BKPyVAN were significantly older than those with asymptomatic replication. These findings suggest that viral genetic determinants play a lesser role in BKPyV replication and its clinical consequences compared to host-related factors.
Aubry et al. (2026) studied this question. Viral genetic determinants play a lesser role in BKPyV replication and clinical consequences compared to host-related factors like older age in kidney transplant recipients.