Preterm infants with bronchopulmonary dysplasia had higher rates of Grade 2 left ventricular diastolic dysfunction (5% vs 1.4%) and pulmonary hypertension (15% vs 7%) compared to control infants.
Cross-Sectional (n=164)
Does bronchopulmonary dysplasia increase the prevalence of left ventricular diastolic dysfunction and pulmonary hypertension in preterm infants at 36 weeks postmenstrual age?
Preterm infants with moderate to severe bronchopulmonary dysplasia have a significantly higher rate of pulmonary hypertension and grade 2 left ventricular diastolic dysfunction at 36 weeks postmenstrual age.
Absolute Event Rate: 5% vs 1.4%
Echocardiographic algorithm based assessment of diastolic function during neonatal period could help in early identification of left ventricular diastolic dysfunction (LVDD) in infants with bronchopulmonary dysplasia (BPD). To screen infants with BPD at 36 weeks postmenstrual age for LVDD. We used conventional Doppler and myocardial deformation parameters suggested in the latest American Society of Echocardiography algorithm to evaluate LV function. Tricuspid-regurgitation velocity, LV shape, LV eccentricity and pulmonary ejection pattern were used to diagnose pulmonary hypertension (PH). The algorithm was then followed using age appropriate cut-off values to identify and grade LVDD. Scans of 71 control infants and 93 infants with BPD were analysed. We noted PH in 15% infants with BPD and 7% control infants. Grade 2 LVDD was seen in 5% infants with BPD compared to 1.4% control infants. Rate of PH and grade 2 LVDD was significantly higher in infants with moderate to severe BPD.
Phad et al. (2026) conducted a cross-sectional in Bronchopulmonary dysplasia (n=164). Bronchopulmonary dysplasia vs. Control infants was evaluated on Grade 2 left ventricular diastolic dysfunction. Preterm infants with bronchopulmonary dysplasia had higher rates of Grade 2 left ventricular diastolic dysfunction (5% vs 1.4%) and pulmonary hypertension (15% vs 7%) compared to control infants.