Sepsis decreased serum concentrations of total cholesterol, HDL cholesterol, and apoproteins A and B, and increased triglycerides compared to controls.
Observational
How does sepsis alter the concentrations of serum lipids, lipoproteins, and apoproteins compared to patients with similar underlying conditions without sepsis?
Sepsis is associated with significant alterations in lipid profiles, specifically decreased total cholesterol, HDL cholesterol, and apoproteins A and B, alongside increased triglycerides.
We studied the alterations in the concentrations of total cholesterol, high-density lipoprotein cholesterol, triglycerides, and apoproteins A and B in serum of 54 patients hospitalized for various reasons, who developed sepsis during their stay. Forty of these patients required intensive care, 14 did not. Another group of patients with the same underlying pathological conditions was used as a control. We found the following: Sepsis causes the concentrations of total cholesterol, high-density lipoprotein cholesterol, and apoproteins A and B in serum to decrease, whereas triglycerides increase. However, these changes are not related to the infectious agent, the underlying illness, or the clinical situation of the patients. The return of serum lipids to more normal concentrations parallels the recovery from sepsis. The positive correlation between the drastically decreased concentrations of high-density lipoprotein cholesterol and the severe hypoalbuminemia in these patients suggests a common pathway for these two abnormalities.
Álvarez et al. (1986) conducted an observational in Sepsis. Sepsis vs. Patients with the same underlying pathological conditions without sepsis was evaluated on Serum concentrations of total cholesterol, high-density lipoprotein cholesterol, triglycerides, and apoproteins A and B. Sepsis decreased serum concentrations of total cholesterol, HDL cholesterol, and apoproteins A and B, and increased triglycerides compared to controls.