Why the study?
Does selective measurement of protamine-inactivated and protamine-resistant lipase activities in postheparin plasma distinguish between hepatic and extra-hepatic lipases in normal subjects and patients with hyperlipoproteinemia?
Population
180 subjects including 100 normal subjects, 12 patients with hyperchylomicronemia, 32 other patients with…
Comparison
Intravenous administration of sodium heparin… vs Normal subjects compared to patients with…
Design
Cross-sectional
Key result
Protamine-inactivated lipase activity was markedly reduced in 12 patients with hyperchylomicronemia (including familial type I) compared to normal subjects, while protamine-resistant lipase was generally normal.
Authors
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Supports protamine-based postheparin lipase assay to identify extrahepatic deficiency; hypothesis-generating for diagnostic use in hyperchylomicronemia.
Cross-Sectional (n=180)
Does selective measurement of protamine-inactivated and protamine-resistant lipase activities in postheparin plasma distinguish between hepatic and extra-hepatic lipases in normal subjects and patients with hyperlipoproteinemia?
p-value: p=<0.001
Selective measurement of postheparin lipase activities using protamine sulfate distinguishes between hepatic and extra-hepatic lipases, revealing specific extra-hepatic lipoprotein lipase deficiencies in patients with familial type I hyperlipoproteinemia.
Krauss et al. (1974) conducted a cross-sectional in Hyperlipoproteinemia (n=180). Hyperchylomicronemia (Type I) vs. Normal subjects was evaluated on Protamine-inactivated (extrahepatic) lipase activity (p=<0.001). Protamine-inactivated lipase activity was markedly reduced in 12 patients with hyperchylomicronemia (including familial type I) compared to normal subjects, while protamine-resistant lipase was generally normal.