HYPERMUT provides a bioinformatics tool for detecting and analyzing hypermutations in viral sequences.
SUMMARY: This program compares sequence sets to a reference sequence, tallies G --> A hypermutations, and presents the results in various tables and graphs, which include dinucleotide context, summaries of all observed nucleotide changes, and stop codons introduced by hypermutation. AVAILABILITY: www.hiv.lanl.gov/HYPERMUT/hypermut.html
Rose et al. (2000) studied this question.