The human small-conductance calcium-activated potassium channel SK1 gene (KCNN1) was localized to chromosome 19p13.1 by radiation hybrid mapping.
The human SK1 (KCNN1) gene, which encodes a small-conductance calcium-activated potassium channel, is mapped to chromosome 19p13.1.
Small-conductance, calcium-activated potassium channels contribute to the afterhyperpolarization in central neurons and other cell types. Because these channels regulate neuronal excitability, defects in their genes could cause excitability disorders. The human cDNA encoding one such channel, SK1 (KCNN1), was recently cloned. Here we describe the gene structure of KCNN1 and its localization by radiation hybrid mapping to chromosome 19p13.1.
Litt et al. (1999) studied this question. Chromosome mapping of KCNN1 was evaluated on Gene structure and chromosomal localization. The human small-conductance calcium-activated potassium channel SK1 gene (KCNN1) was localized to chromosome 19p13.1 by radiation hybrid mapping.