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Abstract High‐temperature organic synthesis can be performed under continuous‐flow conditions in a stainless steel microtubular flow reactor capable of achieving temperatures of 350 °C and 200 bar. Under these extreme experimental environments transformations normally performed in a high‐boiling solvent at reflux temperature – or under sealed‐vessel microwave conditions – can be readily converted to a flow regime by using lower boiling solvents in or near their supercritical state.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Razzaq et al. (2009) studied this question.