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July 13, 2007The Journal of Organic Chemistry134 citations

TiCl4-Catalyzed Indirect Anti-Markovnikov Hydration of Alkynes:  Application to the Synthesis of Benzobfurans

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LALutz AckermannLKLudwig T. Kaspar

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Abstract

An efficient methodology for the indirect anti-Markovnikov hydration of unsymmetrically substituted terminal and internal alkynes is based on TiCl4-catalyzed hydroamination reactions. Its application to ortho-alkynylhaloarenes, followed by a copper-catalyzed O-arylation, provides flexible access to substituted benzobfurans.

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Ackermann et al. (2007) studied this question.

synapsesocial.com/papers/6a202dee68c22b15ac2947b4https://doi.org/10.1021/jo070887i
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